Enzyme promotes aggressive breast cancer

Breast cancer is the most common form of cancer in women globally. Image: Shutterstock

Understanding the role of EZH2 enzymes in promoting breast cancer could lead to more effective treatments.

Histone methyltransferase EZH2 is an enzyme found in humans, encoded by the EZH2 gene, and has linked to the development of aggressive breast cancers. Previous studies suggest that over-expression of the enzyme promotes cancer by inhibiting the function of tumour suppressors, which would normally act as brakes and stop tumour growth.

However, EZH2 is also able to promote cancer by activating genes linked to estrogen receptor-negative breast cancer, according to scientists from the

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